Imfuno yonyango
I-COVID-19 ibangwa lusulelo lwenoveli i-SARS-CoV-2 pathogen, ethi ingene kwaye ingene kwiiseli zomkhosi ngeprotein yayo ye-spike.Okwangoku, kukho ngaphezulu kwe-138.3 yezigidi zeemeko ezibhaliweyo kwihlabathi jikelele, kwaye inani lokufa lisondela kwizigidi ezithathu.
Nangona izitofu zokugonya zamkelwe ukuba zisetyenziswe ngexesha likaxakeka, ukusebenza kwazo ngokuchasene nolunye uhlobo olutsha kuye kwathandatyuzwa.Ngaphezu koko, ukhuselo lokugonya ubuncinci luyi-70% yabemi kuwo onke amazwe ehlabathi lunokuthatha ixesha elide, kuthathelwa ingqalelo isantya sangoku sogonyo, ukusilela kwimveliso yesitofu sokugonya, kunye nemingeni yolungiselelo.
Ihlabathi lisaza kufuna amachiza asebenzayo nakhuselekileyo, ke ngoko, ukungenelela kwisigulo esibi esibangelwa yile ntsholongwane.Uphononongo lwangoku lujolise kumntu ngamnye kunye nomsebenzi we-synergistic we-curcumin kunye ne-nanostructures ngokuchasene nentsholongwane.

Imfuno yonyango
I-COVID-19 ibangwa lusulelo lwenoveli i-SARS-CoV-2 pathogen, ethi ingene kwaye ingene kwiiseli zomkhosi ngeprotein yayo ye-spike.Okwangoku, kukho ngaphezulu kwe-138.3 yezigidi zeemeko ezibhaliweyo kwihlabathi jikelele, kwaye inani lokufa lisondela kwizigidi ezithathu.
Nangona izitofu zokugonya zamkelwe ukuba zisetyenziswe ngexesha likaxakeka, ukusebenza kwazo ngokuchasene nolunye uhlobo olutsha kuye kwathandatyuzwa.Ngaphezu koko, ukhuselo lokugonya ubuncinci luyi-70% yabemi kuwo onke amazwe ehlabathi lunokuthatha ixesha elide, kuthathelwa ingqalelo isantya sangoku sogonyo, ukusilela kwimveliso yesitofu sokugonya, kunye nemingeni yolungiselelo.
Ihlabathi lisaza kufuna amachiza asebenzayo nakhuselekileyo, ke ngoko, ukungenelela kwisigulo esibi esibangelwa yile ntsholongwane.Uphononongo lwangoku lujolise kumntu ngamnye kunye nomsebenzi we-synergistic we-curcumin kunye ne-nanostructures ngokuchasene nentsholongwane.

I-Curcumin
I-Curcumin i-polyphenolic compound eyedwa kwi-rhizome yesityalo se-turmeric, i-Curcuma longa.Yenza i-curcuminoid enkulu kule sityalo, kwi-77% yetotali, ngelixa i-curcumin II encinci yenza i-17%, kwaye i-curcumin III iquka i-3%.
I-Curcumin ibonakaliswe kwaye ifundwe ngokucokisekileyo, njengemolekyuli yendalo enezinto zonyango.Ukunyamezela kwayo kunye nokukhuseleka kubhalwe kakuhle, kunye nomthamo omkhulu we-12 g / ngosuku.
Ukusetyenziswa kwayo kuye kwachazwa njenge-anti-inflammatory, anticancer, kunye ne-antioxidant, kunye ne-antiviral.I-Curcumin icetyiswe njengemolekyuli enokuthi iphilise i-pulmonary edema kunye nezinye iinkqubo eziyingozi ezikhokelela kwi-lung fibrosis elandela i-COVID-19.

I-Curcumin inqanda ii-enzyme zentsholongwane
Oku kucingelwa ukuba kungenxa yokukwazi ukunqanda intsholongwane ngokwayo, kunye nokulungelelanisa iindlela zokudumba.Ilawula i-viral transcription kunye nommiselo, ibophelela ngamandla aphezulu kwi-enzyme ye-viral main protease (Mpro) eyona nto ibalulekileyo ekuphindaphindeni kwaye inqanda i-attachment ye-viral kunye nokungena kwi-cell host.Kunokuphazamisa kwakhona izakhiwo zentsholongwane.
Uluhlu lwayo lwe-antiviral targets lubandakanya i-virus ye-hepatitis C, i-human immunodeficiency virus (i-HIV), i-virus ye-Epstein-Barr kunye ne-influenza A virus.Kuye kwaxelwa ukuba inqanda i-3C-efana ne-protease (3CLpro) ngokusebenzayo ngakumbi kunezinye iimveliso zendalo, kuquka i-quercetin, okanye amachiza afana ne-chloroquine kunye ne-hydroxychloroquine.
Oku kunokuvumela ukunciphisa imithwalo yentsholongwane ngaphakathi kwiseli yomntu ngokukhawuleza kakhulu kunamanye amachiza angaphantsi kwe-inhibitory, kwaye ngaloo ndlela kuthintele ukuqhubela phambili kwesifo kwi-acute breathing distress syndrome (ARDS).
Kwakhona inqanda i-papain-like protease (PLpro) kunye ne-50% ye-inhibitory concentration (IC50) ye-5.7 µM edlula i-quercetin kunye nezinye iimveliso zendalo.

I-Curcumin inqanda i-host cell receptor
Intsholongwane inamathele kwi-cell host target receptor, i-angiotensin-converting enzyme 2 (ACE2).Uphononongo lokumodareyitha lubonise ukuba i-curcumin inqanda ukusebenzisana kwe-virus-receptor ngeendlela ezimbini, ngokuthintela zombini iprotein ye-spike kunye ne-ACE2 receptor.
Nangona kunjalo, i-curcumin ine-bioavailability ephantsi, kuba ayinyibiliki kakuhle emanzini kwaye ayizinzile kwimidiya yamanzi, ngakumbi kwi-pH ephezulu.Xa ilawulwa ngomlomo, idlula ngokukhawuleza i-metabolism ngamathumbu kunye nesibindi.Lo mqobo unokoyiswa ngokusebenzisa i-nanosystems.
Uninzi lwee-nanostructured carriers ezihlukeneyo zingasetyenziselwa le njongo, njenge-nanoemulsions, i-microemulsions, i-nanogels, i-micelles, i-nanoparticles kunye ne-liposomes.Abathwali abanjalo banqanda ukuchithwa kwe-metabolic ye-curcumin, kwandisa ukunyibilika kwayo kunye nokunceda ukuhamba kwiimbumba ze-biological.
Iimveliso ezintathu okanye ngaphezulu ezisekwe kwi-curcumin esekwe kwi-nanostructure sele zifumaneka ngokurhweba, kodwa izifundo ezimbalwa ziye zavavanya ukusebenza kwazo ngokuchasene ne-COVID-19 kwi-vivo.Ezi zibonise amandla okuqulunqa ukulungelelanisa iimpendulo zomzimba kunye nokunciphisa iimpawu zesifo, kwaye mhlawumbi ukukhawuleza ukubuyiswa.